{"entity": "journal", "iuid": "c3320388f3d14ab88072d5b3d699b343", "timestamp": "2026-08-22T08:30:22.036Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Am%20J%20Hum%20Biol.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Am%20J%20Hum%20Biol"}}, "title": "Am J Hum Biol", "issn": "1520-6300", "issn-l": null, "publications_count": 1, "publications": [{"entity": "publication", "iuid": "7cd543caec524bfdba4d14eafc53a33b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7cd543caec524bfdba4d14eafc53a33b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7cd543caec524bfdba4d14eafc53a33b"}}, "title": "Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity.", "authors": [{"family": "Altm\u00e4e", "given": "Signe", "initials": "S", "orcid": "0000-0002-0708-1865", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc13b857bcd94874b57dc0c24b7ba8bc.json"}}, {"family": "Plaza-Florido", "given": "Abel", "initials": "A", "orcid": "0000-0002-5374-3129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0af8876e633441c1b97f9a27257770cf.json"}}, {"family": "Esteban", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-7135-2973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4fcb4c772424f7cac26c1108c6b5109.json"}}, {"family": "Anguita-Ruiz", "given": "Augusto", "initials": "A", "orcid": "0000-0001-6888-1041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/483eff615b1e41cc9ca443a1952e101d.json"}}, {"family": "Krjut\u0161kov", "given": "Kaarel", "initials": "K", "orcid": "0000-0003-1297-1464", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/591c90e9fa694e7295d0a5f94d95cbc1.json"}}, {"family": "Katayama", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7581-5157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac94aab19cbd48d4970404f0d2b2e2ac.json"}}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3101-2285", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae255687b53f4926b4cb9ad06dcf6edc.json"}}, {"family": "Kere", "given": "Juha", "initials": "J", "orcid": "0000-0003-1974-0271", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d26c0765a7349cca1abe211339e8f33.json"}}, {"family": "Radom-Aizik", "given": "Shlomit", "initials": "S"}, {"family": "Ortega", "given": "Francisco B", "initials": "FB", "orcid": "0000-0003-2001-1121", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/283e1e112bc046bc8e79d9ce7cad14ab.json"}}], "type": "randomized controlled trial", "published": "2024-02-00", "journal": {"title": "Am J Hum Biol", "issn": "1520-6300", "volume": "36", "issue": "2", "pages": "e23983", "issn-l": null}, "abstract": "The current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20-week exercise intervention on whole-blood transcriptome profile (RNA-seq) in children with overweight/obesity.\n\nTwenty-four children (10.21 \u00b1 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20-week exercise program (intervention group; n = 10), or to a no-exercise control group (n = 14). Whole-blood transcriptome profile was analyzed using RNA-seq by STRT technique with GlobinLock technology.\n\nFollowing the 20-week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among boys, and 121 genes among girls (p-value <0.05), while after multiple correction, no significant difference between exercise and control groups persisted in gene expression profiles (FDR >0.05). Genes enriched in GO processes and molecular pathways showed different immune response in boys (antigen processing and presentation, infections, and T cell receptor complex) and in girls (Fc epsilon RI signaling pathway) (FDR <0.05).\n\nThese results suggest that 20-week exercise intervention program alters the molecular pathways involved in immune processes in children with overweight/obesity.", "doi": "10.1002/ajhb.23983", "pmid": "37715654", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1937628"}, {"db": "pmc", "key": "PMC11482632"}], "notes": [], "created": "2026-08-21T10:59:44.632Z", "modified": "2026-08-21T10:59:45.516Z"}], "created": "2026-08-21T10:59:45.483Z", "modified": "2026-08-21T10:59:45.483Z"}