{"entity": "journal", "iuid": "6332edcbc5614108b3079c997de64500", "timestamp": "2026-09-26T23:26:09.378Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Am%20Heart%20J.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Am%20Heart%20J"}}, "title": "Am Heart J", "issn": "1097-6744", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "b45ba786ed234242a822e645146fc56f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b45ba786ed234242a822e645146fc56f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b45ba786ed234242a822e645146fc56f"}}, "title": "Plasma proteomics for prediction of subclinical coronary artery calcifications in primary prevention.", "authors": [{"family": "Royer", "given": "Patrick", "initials": "P"}, {"family": "Bj\u00f6rnson", "given": "Elias", "initials": "E"}, {"family": "Adiels", "given": "Martin", "initials": "M"}, {"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB"}, {"family": "Fagerberg", "given": "Linn", "initials": "L"}, {"family": "B\u00e4ckhed", "given": "Fredrik", "initials": "F"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "volume": "271", "pages": "55-67", "issn-l": null}, "abstract": "Recent developments in high-throughput proteomic technologies enable the discovery of novel biomarkers of coronary atherosclerosis. The aims of this study were to test if plasma protein subsets could detect coronary artery calcifications (CAC) in asymptomatic individuals and if they add predictive value beyond traditional risk factors.\n\nUsing proximity extension assays, 1,342 plasma proteins were measured in 1,827 individuals from the Impaired Glucose Tolerance and Microbiota (IGTM) study and 883 individuals from the Swedish Cardiopulmonary BioImage Study (SCAPIS) aged 50-64 years without history of ischaemic heart disease and with CAC assessed by computed tomography. After data-driven feature selection, extreme gradient boosting machine learning models were trained on the IGTM cohort to predict the presence of CAC using combinations of proteins and traditional risk factors. The trained models were validated in SCAPIS.\n\nThe best plasma protein subset (44 proteins) predicted CAC with an area under the curve (AUC) of 0.691 in the validation cohort. However, this was not better than prediction by traditional risk factors alone (AUC = 0.710, P = .17). Adding proteins to traditional risk factors did not improve the predictions (AUC = 0.705, P = .6). Most of these 44 proteins were highly correlated with traditional risk factors.\n\nA plasma protein subset that could predict the presence of subclinical CAC was identified but it did not outperform nor improve a model based on traditional risk factors. Thus, support for this targeted proteomics platform to predict subclinical CAC beyond traditional risk factors was not found.", "doi": "10.1016/j.ahj.2024.01.011", "pmid": "38325523", "labels": [], "xrefs": [{"db": "pii", "key": "S0002-8703(24)00020-6"}], "notes": [], "created": "2026-09-23T11:18:35.877Z", "modified": "2026-09-23T11:18:35.897Z"}, {"entity": "publication", "iuid": "063302de8a6d41c9b3d6df709f1974e2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/063302de8a6d41c9b3d6df709f1974e2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/063302de8a6d41c9b3d6df709f1974e2"}}, "title": "Modifiable lifestyle factors and heart failure: A Mendelian randomization study.", "authors": [{"family": "van Oort", "given": "Sabine", "initials": "S"}, {"family": "Beulens", "given": "Joline W J", "initials": "JWJ"}, {"family": "van Ballegooijen", "given": "Adriana J", "initials": "AJ"}, {"family": "Handoko", "given": "M Louis", "initials": "ML"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "volume": "227", "pages": "64-73", "issn-l": null}, "abstract": "Lifestyle factors may be important targets in the prevention of heart failure. The current knowledge on the relationship between lifestyle factors and heart failure originates mostly from observational studies. The objective of this study was to investigate causal associations of multiple lifestyle factors with heart failure risk by using Mendelian randomization.\n\nWe obtained summary statistics data for single nucleotide polymorphisms associated with the following 5 lifestyle factors at genome-wide significance in genome-wide association studies of European-descent individuals: smoking, alcohol consumption, coffee consumption, physical activity, and sleep duration. The corresponding data for heart failure were acquired from a genome-wide association study comprising 47,309 cases and 930,014 controls of European ancestry. For the primary analyses, we used the inverse-variance weighted method.\n\nGenetic predisposition to smoking initiation (ever smoked regularly) was robustly associated with a higher odds of heart failure (odds ratio: 1.28; 99% CI: 1.21-1.35). Genetically predicted longer sleep duration was associated with a lower odds of heart failure (odds ratio per hour/day: 0.73; 99% CI: 0.60-0.89). We found no associations of alcohol consumption, coffee consumption, and physical activity with heart failure.\n\nThis Mendelian randomization study showed that smoking initiation increases heart failure risk, whereas longer sleep duration decreases the risk of heart failure. Sleep duration should be regarded as novel risk factor in heart failure prevention guidelines. The potential causal role of alcohol and coffee consumption and physical activity for heart failure warrants further investigation in future larger Mendelian randomization analyses.", "doi": "10.1016/j.ahj.2020.06.007", "pmid": "32682105", "labels": [], "xrefs": [{"db": "pii", "key": "S0002-8703(20)30187-3"}], "notes": [], "created": "2026-09-23T08:40:18.368Z", "modified": "2026-09-23T08:40:18.434Z"}, {"entity": "publication", "iuid": "235852526c404b89b2c634858c51a891", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/235852526c404b89b2c634858c51a891.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/235852526c404b89b2c634858c51a891"}}, "title": "Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Drca", "given": "Nikola", "initials": "N"}, {"family": "Jensen-Urstad", "given": "Mats", "initials": "M"}, {"family": "Wolk", "given": "Alicja", "initials": "A"}], "type": "journal article", "published": "2018-01-00", "journal": {"title": "Am Heart J", "issn": "1097-6744", "volume": "195", "pages": "86-90", "issn-l": null}, "abstract": "Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topic.\n\nOur study population comprised 40,009 men from the Cohort of Swedish Men and 32,486 women from the Swedish Mammography Cohort. Incident AF cases were ascertained through linkage with the Swedish National Patient Register. Published cohort studies of chocolate consumption in relation to risk of AF were identified by a PubMed search through September 14, 2017.\n\nDuring a mean follow-up of 14.6 years, AF was diagnosed in 9978 Swedish men and women. Compared with non-consumers, the multivariable hazard ratio of AF for those in the highest category of chocolate consumption (\u22653-4 servings/week) was 0.96 (95% CI 0.88-1.04). In a random-effects meta-analysis of 5 cohort studies, including 180,454 participants and 16,356 AF cases, the hazard ratios of AF were 0.97 (95% CI 0.94-1.01) per 2 servings/week increase in chocolate consumption and 0.96 (95% CI 0.90-1.03) for the highest versus lowest category of chocolate consumption.\n\nAvailable data provide no evidence of an association of chocolate consumption with risk of AF.", "doi": "10.1016/j.ahj.2017.09.013", "pmid": "29224650", "labels": [], "xrefs": [{"db": "pii", "key": "S0002-8703(17)30287-9"}], "notes": [], "created": "2026-09-23T11:41:53.119Z", "modified": "2026-09-23T11:41:53.159Z"}], "created": "2026-09-23T08:40:18.382Z", "modified": "2026-09-23T08:40:18.382Z"}