{"entity": "journal", "iuid": "171b731a940f4609bce9417f4e4e7fcf", "timestamp": "2026-08-20T20:54:02.080Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/Adv%20Biol%20%28Weinh%29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/Adv%20Biol%20%28Weinh%29"}}, "title": "Adv Biol (Weinh)", "issn": "2701-0198", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "526a913e3ddb4d6ca19e18ff12183adf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/526a913e3ddb4d6ca19e18ff12183adf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/526a913e3ddb4d6ca19e18ff12183adf"}}, "title": "Generation of Anterior Segment of the Eye Cells from hiPSCs in Microfluidic Platforms.", "authors": [{"family": "Ko\u00e7ak", "given": "Gamze", "initials": "G", "orcid": "0000-0003-1164-367X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70f4674b253d4eea953180e493478835.json"}}, {"family": "Uyulgan", "given": "Sude", "initials": "S", "orcid": "0000-0003-2188-061X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e5cc0c2e7a34e6b90c5bf0e38a230f6.json"}}, {"family": "Polatl\u0131", "given": "Elifsu", "initials": "E", "orcid": "0000-0002-8960-4534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da4b34be608e4a16b1b9c733e833f5d4.json"}}, {"family": "Sar\u0131", "given": "Vedat", "initials": "V", "orcid": "0000-0002-3891-5869", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8be34175d8c5454794f22cb78a715426.json"}}, {"family": "Kahveci", "given": "Burak", "initials": "B", "orcid": "0000-0001-7041-0986", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32564c59d64c4f6587a7902f58b9c0ba.json"}}, {"family": "Bursali", "given": "Ahmet", "initials": "A"}, {"family": "Binokay", "given": "Leman", "initials": "L", "orcid": "0000-0001-6162-3947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3abf879d5525415a9e92938a8fb4569e.json"}}, {"family": "Re\u00e7ber", "given": "Tuba", "initials": "T", "orcid": "0000-0001-8257-7628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bff4cbdba9fb47ffba373b171e66bdd0.json"}}, {"family": "Nemutlu", "given": "Emirhan", "initials": "E", "orcid": "0000-0002-7337-6215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3779431f902b4e2fa9f04f13785195f9.json"}}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A"}, {"family": "Karak\u00fclah", "given": "G\u00f6khan", "initials": "G", "orcid": "0000-0001-6706-1375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f458878fc8c4980ab867aa3dce34228.json"}}, {"family": "Utine", "given": "Canan Asl\u0131", "initials": "CA", "orcid": "0000-0002-4131-2532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce631edc5eea476589c566367fc3c11e.json"}}, {"family": "G\u00fcven", "given": "Sinan", "initials": "S", "orcid": "0000-0001-5212-5516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8248c62bca5243a18f31a974c2374920.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "volume": "8", "issue": "5", "pages": "e2400018", "issn-l": null}, "abstract": "Ophthalmic diseases affect many people, causing partial or total loss of vision and a reduced quality of life. The anterior segment of the eye accounts for nearly half of all visual impairment that can lead to blindness. Therefore, there is a growing demand for ocular research and regenerative medicine that specifically targets the anterior segment to improve vision quality. This study aims to generate a microfluidic platform for investigating the formation of the anterior segment of the eye derived from human induced pluripotent stem cells (hiPSC) under various spatial-mechanoresponsive conditions. Microfluidic platforms are developed to examine the effects of dynamic conditions on the generation of hiPSCs-derived ocular organoids. The differentiation protocol is validated, and mechanoresponsive genes are identified through transcriptomic analysis. Several culture strategies is implemented for the anterior segment of eye cells in a microfluidic chip. hiPSC-derived cells showed anterior eye cell characteristics in mRNA and protein expression levels under dynamic culture conditions. The expression levels of yes-associated protein and transcriptional coactivator PDZ binding motif (YAP/TAZ) and PIEZO1, varied depending on the differentiation and growth conditions of the cells, as well as the metabolomic profiles under dynamic culture conditions.", "doi": "10.1002/adbi.202400018", "pmid": "38640945", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:27:23.467Z", "modified": "2026-08-20T06:27:23.995Z"}, {"entity": "publication", "iuid": "6d5151bbccf94e4887c6eb2f698be76a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6d5151bbccf94e4887c6eb2f698be76a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6d5151bbccf94e4887c6eb2f698be76a"}}, "title": "An Open-Source Modular Framework for Automated Pipetting and Imaging Applications.", "authors": [{"family": "Ouyang", "given": "Wei", "initials": "W"}, {"family": "Bowman", "given": "Richard W", "initials": "RW"}, {"family": "Wang", "given": "Haoran", "initials": "H"}, {"family": "Bumke", "given": "Kaspar E", "initials": "KE"}, {"family": "Collins", "given": "Joel T", "initials": "JT"}, {"family": "Spjuth", "given": "Ola", "initials": "O"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Diederich", "given": "Benedict", "initials": "B", "orcid": "0000-0003-0453-6286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25fb1523d3854ce59fdfe3841250ac3c.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "volume": "6", "issue": "4", "pages": "e2101063", "issn-l": null}, "abstract": "The number of samples in biological experiments is continuously increasing, but complex protocols and human error in many cases lead to suboptimal data quality and hence difficulties in reproducing scientific findings. Laboratory automation can alleviate many of these problems by precisely reproducing machine-readable protocols. These instruments generally require high up-front investments, and due to the lack of open application programming interfaces (APIs), they are notoriously difficult for scientists to customize and control outside of the vendor-supplied software. Here, automated, high-throughput experiments are demonstrated for interdisciplinary research in life science that can be replicated on a modest budget, using open tools to ensure reproducibility by combining the tools OpenFlexure, Opentrons, ImJoy, and UC2. This automated sample preparation and imaging pipeline can easily be replicated and established in many laboratories as well as in educational contexts through easy-to-understand algorithms and easy-to-build microscopes. Additionally, the creation of feedback loops, with later pipetting or imaging steps depending on the analysis of previously acquired images, enables the realization of fully autonomous \"smart\" microscopy experiments. All documents and source files are publicly available to prove the concept of smart lab automation using inexpensive, open tools. It is believed this democratizes access to the power and repeatability of automated experiments.", "doi": "10.1002/adbi.202101063", "pmid": "34693668", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:27:21.416Z", "modified": "2026-08-20T06:27:21.537Z"}], "created": "2026-08-20T06:27:21.492Z", "modified": "2026-08-20T06:27:21.492Z"}