{"entity": "journal", "iuid": "24bc2e0c3b6a448e89b90fbd595ff869", "timestamp": "2026-08-26T23:01:22.574Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/journal/ACS%20Appl%20Bio%20Mater.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/journal/ACS%20Appl%20Bio%20Mater"}}, "title": "ACS Appl Bio Mater", "issn": "2576-6422", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "e3665bbb3ebf4b5c8944da3ca20574ad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e3665bbb3ebf4b5c8944da3ca20574ad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e3665bbb3ebf4b5c8944da3ca20574ad"}}, "title": "Protein-Decorated Microbubbles for Ultrasound-Mediated Cell Surface Manipulation.", "authors": [{"family": "Brans", "given": "Veerle A", "initials": "VA"}, {"family": "Gray", "given": "Michael D", "initials": "MD"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bd3619c7fd48318bc4c1e7a9910df8.json"}}, {"family": "Stride", "given": "Eleanor P J", "initials": "EPJ", "orcid": "0000-0003-3371-5929", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62dfbf412eda4b119057e6635780cf75.json"}}], "type": "journal article", "published": "2023-12-18", "journal": {"title": "ACS Appl Bio Mater", "issn": "2576-6422", "volume": "6", "issue": "12", "pages": "5746-5758", "issn-l": null}, "abstract": "Delivering cargo to the cell membranes of specific cell types in the body is a major challenge for a range of treatments, including immunotherapy. This study investigates employing protein-decorated microbubbles (MBs) and ultrasound (US) to \"tag\" cellular membranes of interest with a specific protein. Phospholipid-coated MBs were produced and functionalized with a model protein using a metallochelating complex through an NTA(Ni) and histidine residue interaction. Successful \"tagging\" of the cellular membrane was observed using microscopy in adherent cells and was promoted by US exposure. Further modification of the MB surface to enable selective binding to target cells was then achieved by functionalizing the MBs with a targeting protein (transferrin) that specifically binds to a receptor on the target cell membrane. Attachment and subsequent transfer of material from MBs functionalized with transferrin to the target cells significantly increased, even in the absence of US. This work demonstrates the potential of these MBs as a platform for the noninvasive delivery of proteins to the surface of specific cell types.", "doi": "10.1021/acsabm.3c00861", "pmid": "38048163", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10731656"}], "notes": [], "created": "2026-08-20T08:08:15.979Z", "modified": "2026-08-20T08:08:16.053Z"}, {"entity": "publication", "iuid": "cacdfeb7e5f54a72ba28c814254e6390", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cacdfeb7e5f54a72ba28c814254e6390.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cacdfeb7e5f54a72ba28c814254e6390"}}, "title": "Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative.", "authors": [{"family": "Ilkhanizadeh", "given": "Shirin", "initials": "S"}, {"family": "Gracias", "given": "Aileen", "initials": "A"}, {"family": "\u00c5slund", "given": "Andreas K O", "initials": "AKO", "orcid": "0000-0001-5222-9307", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eca2de8d6fb944d3a7894cbab4799629.json"}}, {"family": "B\u00e4ck", "given": "Marcus", "initials": "M"}, {"family": "Simon", "given": "Rozalyn", "initials": "R"}, {"family": "Kavanagh", "given": "Edel", "initials": "E"}, {"family": "Migliori", "given": "Bianca", "initials": "B"}, {"family": "Neofytou", "given": "Christina", "initials": "C"}, {"family": "Nelander", "given": "Sven", "initials": "S"}, {"family": "Westermark", "given": "Bengt", "initials": "B"}, {"family": "Uhrbom", "given": "Lene", "initials": "L"}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}, {"family": "Konradsson", "given": "Peter", "initials": "P"}, {"family": "Teixeira", "given": "Ana I", "initials": "AI", "orcid": "0000-0001-8169-8815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1e6497a9de14f5b901fbca4a223ddad.json"}}, {"family": "Uhl\u00e9n", "given": "Per", "initials": "P"}, {"family": "Joseph", "given": "Bertrand", "initials": "B"}, {"family": "Hermanson", "given": "Ola", "initials": "O", "orcid": "0000-0001-9320-7921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831d43c0539481a96fd114416d5ff4e.json"}}, {"family": "Nilsson", "given": "K Peter R", "initials": "KPR"}], "type": "journal article", "published": "2023-09-18", "journal": {"title": "ACS Appl Bio Mater", "issn": "2576-6422", "volume": "6", "issue": "9", "pages": "3790-3797", "issn-l": null}, "abstract": "There is an urgent need for simple and non-invasive identification of live neural stem/progenitor cells (NSPCs) in the developing and adult brain as well as in disease, such as in brain tumors, due to the potential clinical importance in prognosis, diagnosis, and treatment of diseases of the nervous system. Here, we report a luminescent conjugated oligothiophene (LCO), named p-HTMI, for non-invasive and non-amplified real-time detection of live human patient-derived glioblastoma (GBM) stem cell-like cells and NSPCs. While p-HTMI stained only a small fraction of other cell types investigated, the mere addition of p-HTMI to the cell culture resulted in efficient detection of NSPCs or GBM cells from rodents and humans within minutes. p-HTMI is functionalized with a methylated imidazole moiety resembling the side chain of histidine/histamine, and non-methylated analogues were not functional. Cell sorting experiments of human GBM cells demonstrated that p-HTMI labeled the same cell population as CD271, a proposed marker for stem cell-like cells and rapidly migrating cells in glioblastoma. Our results suggest that the LCO p-HTMI is a versatile tool for immediate and selective detection of neural and glioma stem and progenitor cells.", "doi": "10.1021/acsabm.3c00447", "pmid": "37647213", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10521023"}], "notes": [], "created": "2026-08-20T08:08:13.913Z", "modified": "2026-08-20T08:08:14.055Z"}], "created": "2026-08-20T08:08:14.025Z", "modified": "2026-08-20T08:08:14.025Z"}